Endocrine Abstracts

Tissue-specific transcriptional regulation is achieved by the combined action of transcription factors, co-regulators and components of the basal transcriptional machinery. The goal of our work is to unravel the mechanisms involved in the regulation of the activity of thyroid-specific transcription factors. We have demonstrated that the transcription factor Pax8 is required for the expression of all the thyroid-specific genes that are considered markers of the differentiated p...